Journal article
Anticancer agents against malaria: time to revisit?
- Abstract:
- The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. A possible approach to developing new antimalarials is to find new uses for old drugs. Some anticancer agents such as methotrexate and trimetrexate are active against malaria. However, they are commonly perceived to be toxic and thus not suitable for malaria treatment. In this opinion article, we examine how the toxicity of anticancer agents is just a matter of dose or 'only dose makes the poison', as coined in Paracelsus' law. Thus, the opportunity exists to discover new antimalarials using the anticancer pharmacopoeia.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 191.6KB, Terms of use)
-
- Publisher copy:
- 10.1016/j.pt.2009.12.002
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in parasitology More from this journal
- Volume:
- 26
- Issue:
- 3
- Pages:
- 125-129
- Publication date:
- 2010-03-01
- DOI:
- EISSN:
-
1471-5007
- ISSN:
-
1471-4922
- Language:
-
English
- Keywords:
- UUID:
-
uuid:782e3a96-591f-43e5-97a0-5b7203583d3c
- Local pid:
-
pubs:53954
- Source identifiers:
-
53954
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2010
- Notes:
- Copyright © 2009 Elsevier Ltd. Under a Creative Commons license. Open Access funded by Wellcome Trust.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record