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Primary microRNA transcripts are processed co-transcriptionally.

Abstract:

microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II (Pol II)-derived transcripts by two RNase III processing reactions: Drosha cleavage of nuclear pri-miRNAs and Dicer cleavage of cytoplasmic pre-miRNAs. Here we show that Drosha cleavage occurs during transcription acting on both independently transcribed and intron-encoded miRNAs. We also show that both 5'-3' and 3'-5' exonucleases associate with the sites where co-transcriptional Drosha cleavage occurs, promoting int...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb.1475

Authors


Morlando, M More by this author
Ballarino, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Bozzoni, I More by this author
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Journal:
Nat Struct Mol Biol
Volume:
15
Issue:
9
Pages:
902-909
Publication date:
2008-08-31
DOI:
ISSN:
1545-9985
URN:
uuid:77ee2847-7e54-46b8-8900-9a9ffbbe18f2
Source identifiers:
10319
Local pid:
pubs:10319
Language:
English

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