Journal article icon

Journal article

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

Abstract:

BACKGROUND AND PURPOSE: Tumour hypoxia contributes to failure of cancer treatment through its ability to protect against therapy and adversely influence tumour biology. In particular, several studies suggest that hypoxia promotes metastasis. Hypoxia-induced cellular changes are mediated by oxygen-sensitive signaling pathways that activate downstream transcription factors. We have investigated the induction and transcriptional regulation of a novel metastasis-associated gene, LAMP3 during hyp...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Rzymski, T More by this author
Rouschop, KM More by this author
Koritzinsky, M More by this author
Expand authors...
Journal:
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume:
92
Issue:
3
Pages:
450-459
Publication date:
2009-09-05
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
URN:
uuid:77ca8ac0-6aec-481e-93f7-8484f5726c87
Source identifiers:
125266
Local pid:
pubs:125266

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP