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Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors.

Abstract:

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis. Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biochemical Society symposium
Volume:
70
Issue:
70
Pages:
201-212
Publication date:
2003-01-01
EISSN:
1744-1439
ISSN:
0067-8694
URN:
uuid:7790f741-cc22-4e8c-8073-9569dbd7dc58
Source identifiers:
226739
Local pid:
pubs:226739

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