Turbulent dynamics and whole-brain modeling: toward new clinical applications for traumatic brain injury

Journal article

Traumatic Brain Injury (TBI) is a prevalent disorder mostly characterized by persistent impairments in cognitive function that poses a substantial burden on caregivers and the healthcare system worldwide. Crucially, severity classification is primarily based on clinical evaluations, which are non-specific and poorly predictive of long-term disability. In this Mini Review, we first provide a description of our model-free and model-based approaches within the turbulent dynamics framework as well as our vision on how they can potentially contribute to provide new neuroimaging biomarkers for TBI. In addition, we report the main findings of our recent study examining longitudinal changes in moderate-severe TBI (msTBI) patients during a one year spontaneous recovery by applying the turbulent dynamics framework (model-free approach) and the Hopf whole-brain computational model (model-based approach) combined with in silico perturbations. Given the neuroinflammatory response and heightened risk for neurodegeneration after TBI, we also offer future directions to explore the association with genomic information. Moreover, we discuss how whole-brain computational modeling may advance our understanding of the impact of structural disconnection on whole-brain dynamics after msTBI in light of our recent findings. Lastly, we suggest future avenues whereby whole-brain computational modeling may assist the identification of optimal brain targets for deep brain stimulation to promote TBI recovery.Fil: Martínez Molina, Noelia. Universitat Pompeu Fabra; EspañaFil: Sanz Perl Hernandez, Yonatan. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Escrichs, Anira. Universitat Pompeu Fabra; EspañaFil: Kringelbach, Morten L.. University of Oxford; Reino UnidoFil: Deco, Gustavo. Universitat Pompeu Fabra; Españ

Authors: Martínez-Molina, N; Sanz-Perl, Y; Escrichs, A; Kringelbach, ML; Deco, G

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Frontiers Media
• Journal: Frontiers in Neuroinformatics
• Volume: 18
• Pages: 1382372-1382372
• Article number: 1382372
• Publication date: 2024-03-25
• DOI: 10.3389/fninf.2024.1382372
• EISSN: 1662-5196
• ISSN: 1662-5196
• Language: English
• Keywords: Neuroimaging; Neurodegeneration; Pathology; Computer science; Psychiatry; Traumatic brain injury; Disconnection; Injury prevention; Neuroscience; Poison control; Cognition; Computational model; Chronic traumatic encephalopathy; Artificial intelligence; Psychology; Medicine; Concussion