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Voltage sensitive dye imaging of transient neuronal assemblies in brain slices under hyperbaric conditions.

Abstract:

We have developed a high pressure optical cell to study large-scale transient neuronal coalitions--"assemblies" using voltage sensitive dye (VSD) fluorescence combined with fast CCD imaging of brain slices under hyperbaric conditions. The new cell has been tested at pressures up to P = 150-200 atm, corresponding to the range over which effects such as "pressure-reversal" of anaesthesia have been described previously. Brain slices were maintained in a flow of artificial cerebrospinal fluid (aC...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Undersea and hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
Volume:
35
Issue:
1
Pages:
35-40
Publication date:
2008-01-01
ISSN:
1066-2936
URN:
uuid:771cba44-c46d-4dd2-8fb2-d4ce23f857f8
Source identifiers:
185289
Local pid:
pubs:185289

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