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Plasma pharmacokinetics of once- versus twice-daily lamivudine and abacavir: simplification of combination treatment in HIV-1-infected children (PENTA-13).

Abstract:

BACKGROUND: There are few data on plasma and intracellular pharmacokinetics (PK) of once-daily (q24h) nucleoside analogues in HIV-infected children. METHODS: Children aged 2-13 years receiving combination treatment containing lamivudine (3TC) (4 mg/kg) and/or abacavir (ABC) (8 mg/kg) twice daily (q12h) were included in this single-arm, open-label, crossover study. Intensive plasma PK sampling was performed at steady state, after which children switched to q24h dosing and PK sampling was repea...

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Publication status:
Published

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Authors


Bergshoeff, A More by this author
Verweij, C More by this author
Farrelly, L More by this author
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Journal:
Antiviral therapy
Volume:
10
Issue:
2
Pages:
239-246
Publication date:
2005
EISSN:
2040-2058
ISSN:
1359-6535
URN:
uuid:76b687f9-e1f8-46dc-a27a-1e8e8ec2738f
Source identifiers:
423023
Local pid:
pubs:423023

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