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Journal article

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

Abstract:

The Fanconi anemia (FA) pathway plays a central role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular responses to replication stress. Homologous recombination (HR), the error-free pathway for double-strand break (DSB) repair, is required during physiological cell cycle progression for the repair of replication-associated DNA damage and protection of stalled replication forks. Substantial crosstalk between the two pathways has recently been unravelled, in that key HR ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.15252/embj.201693860

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Publisher:
EMBO Press Publisher's website
Journal:
The EMBO journal Journal website
Volume:
35
Issue:
9
Pages:
909-923
Publication date:
2016-04-01
Acceptance date:
2016-03-08
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:76850dc9-939b-462d-87a0-bf83d497d2ec
Source identifiers:
614041
Local pid:
pubs:614041
Paper number:
9

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