Journal article
An empiric risk score to guide PrEP targeting among MSM in coastal Kenya
- Abstract:
- Men who have sex with men (MSM), who have heterogeneous HIV-acquisition risks are not specifically targeted in Kenyan pre-exposure prophylaxis (PrEP) guidelines. We used data from an open cohort, which followed 753 initially HIV-negative MSM participants for more than 1378.5 person-years, to develop an empiric risk score for targeting PrEP delivery. Independent predictors of incident HIV-1 infection in this cohort were an age of 18-24 years, having only male sex partners, having receptive anal intercourse, having any unprotected sex, and having group sex. Poisson model coefficients were used to assign a numeric score to each statistically significant predictor. A risk score of ≥ 1 corresponded to an HIV-1 incidence of ≥ 2.2 [95% confidence interval (CI) 1.2-4.1] and identified 81.3% of the cohort participants as being at high risk for HIV-1 acquisition. The area under the receiver operating characteristic curve was 0.76 (95% CI 0.71-0.80). This empiric risk score may help Kenyan health care providers to assess HIV-1 acquisition risk and encourage PrEP uptake by high-risk MSM.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 582.5KB, Terms of use)
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- Publisher copy:
- 10.1007/s10461-018-2141-2
Authors
- Publisher:
- Springer
- Journal:
- AIDS and Behavior More from this journal
- Volume:
- 22
- Issue:
- S1
- Pages:
- 35-44
- Publication date:
- 2018-05-16
- DOI:
- EISSN:
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1573-3254
- ISSN:
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1090-7165
- Pmid:
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29767324
- Language:
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English
- Keywords:
- Pubs id:
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pubs:853013
- UUID:
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uuid:767fb6ae-b23e-43c3-a1ec-d429da6d7c23
- Local pid:
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pubs:853013
- Source identifiers:
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853013
- Deposit date:
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2018-11-20
- ARK identifier:
Terms of use
- Copyright holder:
- Wahome et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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