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A time-series analysis of any short-term effects of meteorological and air pollution factors on preterm births in London, UK.

Abstract:
Although much is known about the incidence and burden of preterm birth, its biological mechanisms are not well understood. While several studies have suggested that high levels of air pollution or exposure to particular climatic factors may be associated with an increased risk of preterm birth, other studies do not support such an association. To determine whether exposure to various environmental factors place a large London-based population at higher risk for preterm birth, we analyzed 482,568 births that occurred between 1988 and 2000 from the St. Mary's Maternity Information System database. Using an ecological study design, any short-term associations between preterm birth and various environmental factors were investigated using time-series regression techniques. Environmental exposures included air pollution (ambient ozone and PM(10)) and climatic factors (temperature, rainfall, sunshine, relative humidity, barometric pressure, and largest drop in barometric pressure). In addition to exposure on the day of birth, cumulative exposure up to 1 week before birth was investigated. The risk of preterm birth did not increase with exposure to the levels of ambient air pollution or meteorological factors experienced by this population. Cumulative exposure from 0 to 6 days before birth also did not show any significant effect on the risk of preterm birth. This large study, covering 13 years, suggests that there is no association between preterm births and recent exposure to ambient air pollution or recent changes in the weather.
Publication status:
Published

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Publisher copy:
10.1016/j.envres.2007.10.003

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author


Journal:
Environmental research More from this journal
Volume:
106
Issue:
2
Pages:
185-194
Publication date:
2008-02-01
DOI:
EISSN:
1096-0953
ISSN:
0013-9351


Language:
English
Keywords:
Pubs id:
pubs:459382
UUID:
uuid:763bfa06-5e96-4cce-a394-d1233f596150
Local pid:
pubs:459382
Source identifiers:
459382
Deposit date:
2014-06-11
ARK identifier:

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