Declining Antibody Affinity Over Time After Human Vaccination With a <i>Plasmodium falciparum</i> Merozoite Vaccine Candidate

Journal article

UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12607000552482

Authors: Persson, KEM; Horton, JL; Kurtovic, L; McCarthy, JS; Anders, RF

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: The Journal of Infectious Diseases
• Volume: 230
• Issue: 3
• Pages: e753-e757
• Publication date: 2024-05-09
• DOI: 10.1093/infdis/jiae259
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Vaccination; Immunology; Antibody; Immunity; Immune system; Biology; Malaria; Plasmodium falciparum; Malaria vaccine; Virology; Medicine