Journal article icon

Journal article

Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men.

Abstract:
We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (< or = 20 CAG repeats) were associated with AD (adjusted odds ratio = 2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (< 65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.
Publication status:
Published

Actions


Access Document


Authors


Lehmann, DJ More by this author
Butler, HT More by this author
Warden, DR More by this author
Combrinck, M More by this author
Expand authors...
Journal:
Neuroscience letters
Volume:
340
Issue:
2
Pages:
87-90
Publication date:
2003-04-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:761be912-40b7-4b72-be4b-0f33e1839ee8
Source identifiers:
71806
Local pid:
pubs:71806

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP