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Mesoscale modelling of starch digestion

Abstract:
An idealised mesoscale model of the enzymatic digestion of starch modelled as a polymer aggregate is used to study the effect of various enzyme properties, such as the enzyme efficiency, range and radius, on the rate at which monomers are released from the aggregate. Depending on the enzyme efficiency the process is found to be either reaction- or diffusion-limited. Additionally the digestion rate is found to be proportional to the volume around each bond that is accessible to the enzyme, which is determined by the range and radius of the enzyme. Simulations of uniformly mixed susceptible and resistant polymers reveal no significant effect on the digestion of the susceptible polymers due to the presence of the resistant polymers.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/00268976.2024.2445770

Authors

More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0001-8268-5469



Publisher:
Taylor & Francis
Journal:
Molecular Physics More from this journal
Volume:
123
Issue:
15
Article number:
e2445770
Publication date:
2025-01-07
Acceptance date:
2024-12-16
DOI:
EISSN:
1362-3028
ISSN:
0026-8976


Language:
English
Keywords:
Pubs id:
2078531
Local pid:
pubs:2078531
Deposit date:
2025-05-13
ARK identifier:

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