Treg cells suppress osteoclast formation: a new link between the immune system and bone.

Journal article

OBJECTIVE: To investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton. METHODS: Regulatory CD4+,CD25+,Foxp3+ T cells were isolated and purified from the spleen and cocultured with CD11b+ osteoclast precursor cells isolated from bone marrow. Osteoclastogenesis and bone erosion were assessed by tartrate-resistant acid phosphatase staining and pit resorption assay, respectively. In addition, Transwell ...

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Authors: Zaiss, M; Axmann, R; Zwerina, J; Polzer, K; Gückel, E

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 56
• Issue: 12
• Pages: 4104-4112
• Publication date: 2007-12-01
• DOI: 10.1002/art.23138
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Immune System; Forkhead Transcription Factors; Antigens, Differentiation; Interleukin-2 Receptor alpha Subunit; T-Lymphocytes, Regulatory; Bone and Bones; Macrophage Colony-Stimulating Factor; Cells, Cultured; Mice, Inbred C57BL; Mice; CTLA-4 Antigen; Animals; Cell Differentiation; RANK Ligand; Cell Communication; Osteoclasts; Female; Antigens, CD; Antigens, CD11