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Journal article

Treg cells suppress osteoclast formation: a new link between the immune system and bone.

Abstract:

OBJECTIVE: To investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton. METHODS: Regulatory CD4+,CD25+,Foxp3+ T cells were isolated and purified from the spleen and cocultured with CD11b+ osteoclast precursor cells isolated from bone marrow. Osteoclastogenesis and bone erosion were assessed by tartrate-resistant acid phosphatase staining and pit resorption assay, respectively. In addition, Transwell ...

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Publication status:
Published

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Publisher copy:
10.1002/art.23138

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Journal:
Arthritis and rheumatism
Volume:
56
Issue:
12
Pages:
4104-4112
Publication date:
2007-12-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:7610eaea-2709-4629-bf1d-416096f4aa02
Source identifiers:
223520
Local pid:
pubs:223520

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