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Identifying and quantifying radiation damage at the atomic level

Abstract:

Radiation damage impedes macromolecular diffraction experiments. Alongside the well known effects of global radiation damage, site-specific radiation damage affects data quality and the veracity of biological conclusions on protein mechanism and function. Site-specific radiation damage follows a relatively predetermined pattern, in that different structural motifs are affected at different dose regimes: in metal-free proteins, disulfide bonds tend to break first followed by the decarboxylatio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1107/S1600577515002131

Authors


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Institution:
University of Oxford
Research group:
Garman Group
Oxford college:
St Hilda's College
Department:
Medical Sciences Division - Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Garman Group
Department:
Medical Sciences Division - Biochemistry
Role:
Author
Publisher:
International Union of Crystallography Publisher's website
Journal:
Journal of Synchrotron Radiation Journal website
Volume:
22
Pages:
201-212
Publication date:
2015-01-01
DOI:
EISSN:
1600-5775
ISSN:
0909-0495
URN:
uuid:75f30844-36f9-476f-8eb2-9e77eb714fd6
Local pid:
ora:11312

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