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Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.

Abstract:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy of humans, affects over 400 million people. The geographical correlation of its distribution with the historical endemicity of malaria suggests that this disorder has risen in frequency through natural selection by malaria. However, attempts to confirm that G6PD deficiency is protective in case-control studies of malaria have yielded conflicting results. Hence, for this X-linked disorder, it is unclear whether bo...

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Publication status:
Published

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Publisher copy:
10.1038/376246a0

Authors


Ruwende, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
Nature
Volume:
376
Issue:
6537
Pages:
246-249
Publication date:
1995-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:75e0c7be-f1e6-4291-b923-dd58ce8e7da3
Source identifiers:
6949
Local pid:
pubs:6949

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