Journal article icon

Journal article

Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.

Abstract:

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental data that permit a detailed comparison to be made of the behaviour of two of these amyloidogenic variants, I56T and D67H, under identical conditions. Hydrogen/deuterium exchange experiments monitored by NMR and mass spectrometry reveal that, despite their different locations and the different effects...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2004.11.020

Authors


Expand authors...
Journal:
Journal of molecular biology
Volume:
346
Issue:
3
Pages:
773-788
Publication date:
2005-02-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:75d5503e-4ad4-48fc-9547-1c7f08a404b0
Source identifiers:
59271
Local pid:
pubs:59271

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP