Journal article

Regioselective nucleophilic addition to pyridinium salts: a new route to substituted dihydropyridones.

Abstract:: The regioselective addition of nucleophiles to pyridinium salts generates an intermediate enol-ether, which can be hydrolyzed in situ to provide a range of dihydropyridones. Certain Grignards have shown inherent differences in the regioselectivity of addition to these salts, and this difference can be tuned to give single regioisomeric addition products. The dihydropyridone products can be further manipulated in many ways using standard transformations.

Publication status:: Published

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APA Style

Donohoe, T., Connolly, M., & Walton, L. (2009). Regioselective nucleophilic addition to pyridinium salts: a new route to substituted dihydropyridones. Organic Letters, 11(23), 5562–5565.

MLA Style

Donohoe, T., et al. “Regioselective Nucleophilic Addition to Pyridinium Salts: a New Route to Substituted Dihydropyridones.” Organic Letters, vol. 11, no. 23, 2009, pp. 5562–65.

Chicago Style

Donohoe, T, M Connolly, and L Walton. 2009. “Regioselective Nucleophilic Addition to Pyridinium Salts: a New Route to Substituted Dihydropyridones.” Organic Letters 11 (23): 5562–65.
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Publisher copy:: 10.1021/ol902402v

Authors

+ Donohoe, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Connolly, M More by this author

Role:: Author

+ Walton, L More by this author

Role:: Author

Journal:: Organic letters More from this journal
Volume:: 11
Issue:: 23
Pages:: 5562-5565
Publication date:: 2009-12-01
DOI:: 10.1021/ol902402v
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
Keywords:: Salts

Stereoisomerism

Pyridones

Pyridinium Compounds

Molecular Structure
Pubs id:: pubs:34960
UUID:: uuid:75cacd44-ac41-4546-a655-1f1fae15489e
Local pid:: pubs:34960
Source identifiers:: 34960
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2009

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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