- Abstract:
- The regioselective addition of nucleophiles to pyridinium salts generates an intermediate enol-ether, which can be hydrolyzed in situ to provide a range of dihydropyridones. Certain Grignards have shown inherent differences in the regioselectivity of addition to these salts, and this difference can be tuned to give single regioisomeric addition products. The dihydropyridone products can be further manipulated in many ways using standard transformations.
- Publication status:
- Published
- Publisher copy:
- 10.1021/ol902402v
-
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- Journal:
- Organic letters
- Volume:
- 11
- Issue:
- 23
- Pages:
- 5562-5565
- Publication date:
- 2009-12-05
- DOI:
- EISSN:
-
1523-7052
- ISSN:
-
1523-7060
- URN:
-
uuid:75cacd44-ac41-4546-a655-1f1fae15489e
- Source identifiers:
-
34960
- Local pid:
- pubs:34960
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Regioselective nucleophilic addition to pyridinium salts: a new route to substituted dihydropyridones.
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