PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Journal article

Insulin secretion from pancreatic beta cells is stimulated by glucose metabolism. However, the relative importance of metabolizing glucose via mitochondrial oxidative phosphorylation versus glycolysis for insulin secretion remains unclear. von Hippel-Lindau (VHL) tumor suppressor protein, pVHL, negatively regulates hypoxia-inducible factor HIF1alpha, a transcription factor implicated in promoting a glycolytic form of metabolism. Here we report a central role for the pVHL-HIF1alpha pathway in ...

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Authors: Zehetner, J; Danzer, C; Collins, S; Eckhardt, K; Gerber, P

• Publication status: Published
• Journal: Genes and development
• Volume: 22
• Issue: 22
• Pages: 3135-3146
• Publication date: 2008-11-01
• DOI: 10.1101/gad.496908
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Electrophysiology; Cells, Cultured; Mice, Mutant Strains; Hypoxia-Inducible Factor 1, alpha Subunit; Animals; Polymerase Chain Reaction; Glucose Tolerance Test; Insulin; Fluorometry; Mice; Insulin-Secreting Cells; Carbohydrate Metabolism; Von Hippel-Lindau Tumor Suppressor Protein; Immunoblotting