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Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

Abstract:

In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therapy-naïve subjects were studied in detail between 1 and 87 weeks following onset of symptoms of acute HIV-1 infection. Synthetic peptides representing the autologous transmitted/founder HIV-1 sequenc...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1001273

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Borrow, P
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Funding agency for:
Mcmichael, AJ
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Funding agency for:
Mcmichael, AJ
Duke University Center for AIDS Research More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
7
Issue:
2
Pages:
e1001273
Publication date:
2011-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:75b4a862-44d2-47b2-a7f8-0d576bd8ac90
Source identifiers:
120166
Local pid:
pubs:120166

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