Journal article icon

Journal article

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

Abstract:

Recent biochemical observations have helped redefine antigenic components within the voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now divided into likely pathogenic entities, which target the extracellular domains of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein 2 (CASPR2), and species that target intracellular neuronal components and are likely non-pathogenic. This distinction has enhanced clinical practice as direct determinat...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1136/jnnp-2017-315720

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
St Hildas College
Role:
Author
UCB – Oxford University Alliance More from this funder
British Medical Association More from this funder
Epilepsy Research UK More from this funder
Fulbright UK–US commission More from this funder
Expand funders...
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Volume:
89
Pages:
526-534
Publication date:
2017-10-21
Acceptance date:
2017-09-22
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pubs id:
pubs:733033
URN:
uri:75a810d9-0122-495d-8b3c-a2a73f113df5
UUID:
uuid:75a810d9-0122-495d-8b3c-a2a73f113df5
Local pid:
pubs:733033

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP