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Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study

Abstract:

Background: The global prevalence of X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is thought to be a result of selection by malaria, but epidemiological studies have yielded confusing results. We investigated the relationships between G6PD deficiency and both malaria and non-malarial illnesses among children in Kenya.


Methods: We did this study in Kilifi County, Kenya, where the G6PD c.202T allele is the only significant cause o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s2352-3026(15)00152-0

Authors


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Role:
Author
ORCID:
0000-0003-1746-7873
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Centre for Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Centre for Human Genetics
Role:
Author

Contributors

Role:
Contributor


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Funder identifier:
https://ror.org/029chgv08
Grant:
092654/Z/10/A
084535/Z/07/B
091758/Z/10/Z
077383/Z/05/Z
090770/Z/09/Z
090532/Z/09/Z
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Funder identifier:
https://ror.org/00k4n6c32
Grant:
242095
More from this funder
Funder identifier:
https://ror.org/03x94j517
Grant:
MR/M006212/1
G0600718
G19/9


Publisher:
Elsevier
Journal:
Lancet Haematology More from this journal
Volume:
2
Issue:
10
Pages:
e437-e444
Place of publication:
England
Publication date:
2015-09-22
Acceptance date:
2015-08-07
DOI:
EISSN:
2352-3026
Pmid:
26686045


Language:
English
Keywords:
Pubs id:
571313
Local pid:
pubs:571313
Deposit date:
2025-01-25

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