Journal article

Comparison of a batch and flow approach for the lipase-catalyzed resolution of a Cyclopropanecarboxylate ester, a key building block for the synthesis of ticagrelor

Abstract:: In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Hugentobler, K., Rasparini, M., Thompson, L., Jolley, K., Blacker, A., & Turner, N. (2016). Comparison of a batch and flow approach for the lipase-catalyzed resolution of a Cyclopropanecarboxylate ester, a key building block for the synthesis of ticagrelor. Organic Process Research & Development, 21(2), 195–199.

MLA Style

Hugentobler, K, et al. “Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, a Key Building Block for the Synthesis of Ticagrelor.” Organic Process Research & Development, vol. 21, no. 2, 2016, pp. 195–99.

Chicago Style

Hugentobler, K, M Rasparini, L Thompson, K Jolley, A Blacker, and N Turner. 2016. “Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, a Key Building Block for the Synthesis of Ticagrelor.” Organic Process Research & Development 21 (2): 195–99.
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Publisher copy:: 10.1021/acs.oprd.6b00346

Authors

+ Hugentobler, K More by this author

Role:: Author

+ Rasparini, M More by this author

Role:: Author

+ Thompson, L More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Inorganic Chemistry
Role:: Author

+ Jolley, K More by this author

Role:: Author

+ Blacker, A More by this author

Role:: Author

More authors...

+ Royal Society More from this funder

Grant:: Wolfson Research Merit Award

+ CHEMO More from this funder

+ AstraZeneca More from this funder

+ Engineering and Physical Sciences Research Council More from this funder

Publisher:: American Chemical Society
Journal:: Organic Process Research & Development More from this journal
Volume:: 21
Issue:: 2
Pages:: 195-199
Publication date:: 2016-12-01
DOI:: 10.1021/acs.oprd.6b00346
ISSN:: 1520-586X, 1083-6160

Keywords:: ticagrelor

enzyme catalysis

batch reactor

Thermomyces lanuginosus lipase

flow chemistry
Pubs id:: pubs:733134
UUID:: uuid:758a0383-0268-4e8c-a5c6-7d281cc6f069
Local pid:: pubs:733134
Source identifiers:: 733134
Deposit date:: 2017-10-06
ARK identifier:: ark:/29072/ora_758a038302684e8ca5c67d281cc6f069

Terms of use

Copyright date:: 2016

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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