Journal article
Determination of CSF GFAP, CCN5, and vWF levels enhances the diagnostic accuracy of clinically defined MS from non-MS patients with CSF oligoclonal bands
- Abstract:
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Background: Inclusion of cerebrospinal fluid (CSF) oligoclonal IgG bands (OCGB) in the revised McDonald criteria increases the sensitivity of diagnosis when dissemination in time (DIT) cannot be proven. While OCGB negative patients are unlikely to develop clinically definite (CD) MS, OCGB positivity may lead to an erroneous diagnosis in conditions that present similarly, such as neuromyelitis optica spectrum disorders (NMOSD) or neurosarcoidosis.
Objective: To identify specific, OCGB-complementary, biomarkers to improve diagnostic accuracy in OCGB positive patients.
Methods: We analysed the CSF metabolome and proteome of CDMS (n=41) and confirmed non-MS patients (n=64) comprising a range of CNS conditions routinely encountered in neurology clinics.
Results: OCGB discriminated between CDMS and non-MS with high sensitivity (85%), but low specificity (67%), as previously described. Machine learning methods revealed CCN5 levels provide greater accuracy, sensitivity, and specificity than OCGB (79%, +5%; 90%, +5%; and 72%, +5% respectively) while glial fibrillary acidic protein (GFAP) identified CDMS with 100% specificity (+33%). A multiomics approach improved accuracy further to 90% (+16%).
Conclusion: The measurement of a few additional CSF biomarkers could be used to complement OCGB and improve the specificity of MS diagnosis when clinical and radiological evidence of DIT is absent.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 263.8KB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2021.811351
Authors
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MC_PC_15029
- Funder identifier:
- https://ror.org/043fwdk81
- Grant:
- 59
- Publisher:
- Frontiers
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 12
- Article number:
- 811351
- Place of publication:
- Switzerland
- Publication date:
- 2022-02-04
- Acceptance date:
- 2021-12-27
- DOI:
- EISSN:
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1664-3224
- Pmid:
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35185866
- Language:
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English
- Keywords:
- Pubs id:
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1241257
- Local pid:
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pubs:1241257
- Deposit date:
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2024-09-05
Terms of use
- Copyright holder:
- Probert et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 Probert, Yeo, Zhou, Sealey, Arora, Palace, Claridge, Hillenbrand, Oechtering, Kuhle, Leppert and Anthony. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Notes:
- A correction has been applied to this article in: https://doi.org/10.3389/fimmu.2022.1095038
- Licence:
- CC Attribution (CC BY)
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