Journal article icon

Journal article

A comparison of 2-hydroxyglutarate detection at 3 T and 7 T with long-TE semi-LASER

Abstract:

Abnormally high levels of the ‘oncometabolite’ 2-hydroxyglutarate (2-HG) occur in many grade II and III gliomas and correlate with mutations in the genes of isocitrate dehydrogenase (IDH) isoforms. In vivo measurement of 2-HG in patients, using MR spectroscopy, has largely been carried out at 3 T, yet signal overlap continues to pose a challenge for 2-HG detection. To combat this, several groups have proposed MRS methods at ultra-high field (≥ 7 T) where theoretical increases in signal-to-noi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1002/nbm.3886

Authors


Berrington, A More by this author
More by this author
Institution:
University of Oxford
Division:
MSD Division
Department:
Clinical Neuroscience
More by this author
Institution:
University of Oxford
Division:
MSD Division
Department:
Clinical Neuroscience
de Pennington, N More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Merton College
Expand authors...
Publisher:
Wiley Publisher's website
Journal:
NMR in Biomedicine Journal website
Volume:
31
Issue:
3
Pages:
1-9
Publication date:
2018-01-05
Acceptance date:
2017-11-22
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Pubs id:
pubs:811966
URN:
uri:7569c98c-c7f5-4571-8e2e-b7cb0c362361
UUID:
uuid:7569c98c-c7f5-4571-8e2e-b7cb0c362361
Local pid:
pubs:811966

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP