Journal article

Pre-mRNA processing reaches back to transcription and ahead to translation.

Abstract:: The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.

Publication status:: Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Moore, M., & Proudfoot, N. (2009). Pre-mRNA processing reaches back to transcription and ahead to translation. Cell, 136(4), 688–700.

MLA Style

Moore, M, and N Proudfoot. “Pre-MRNA Processing Reaches Back to Transcription and Ahead to Translation.” Cell, vol. 136, no. 4, 2009, pp. 688–700.

Chicago Style

Moore, M, and N Proudfoot. 2009. “Pre-MRNA Processing Reaches Back to Transcription and Ahead to Translation.” Cell 136 (4): 688–700.
Print

Access Document

Publisher copy:: 10.1016/j.cell.2009.02.001

Authors

+ Moore, M More by this author

Role:: Author

+ Proudfoot, N More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pathology Dunn School
Role:: Author

Journal:: Cell More from this journal
Volume:: 136
Issue:: 4
Pages:: 688-700
Publication date:: 2009-02-01
DOI:: 10.1016/j.cell.2009.02.001
EISSN:: 1097-4172
ISSN:: 0092-8674

Language:: English
Keywords:: Protein Biosynthesis

Animals

Transcription, Genetic

Humans

RNA Precursors

RNA Stability

RNA Processing, Post-Transcriptional

Feedback

Gene Expression Regulation
Pubs id:: pubs:8340
UUID:: uuid:7564cd11-220a-425a-9915-9eadded79318
Local pid:: pubs:8340
Source identifiers:: 8340
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_7564cd11220a425a99159eadded79318

Terms of use

Copyright date:: 2009

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP