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Journal article

A common mitochondrial DNA variant associated with susceptibility to dilated cardiomyopathy in two different populations.

Abstract:

Idiopathic dilated cardiomyopathy is a recognised manifestation of mitochondrial disease due to specific mitochondrial (mt) DNA mutations. However, whether mtDNA polymorphisms predispose to sporadic dilated cardiomyopathy is not known. We analysed two populations with this disorder for a general mtDNA variant (T16189C), previously implicated in susceptibility to type 2 diabetes. We noted an increased frequency of the polymorphism in both populations compared with controls (p=0.002). The polym...

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Publication status:
Published

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Journal:
Lancet
Volume:
357
Issue:
9264
Pages:
1265-1267
Publication date:
2001-04-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:75599bb9-10d4-4f5b-bce6-8499b46d5440
Source identifiers:
104310
Local pid:
pubs:104310

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