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Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX

Abstract:

Carbonic anhydrase IX (CAIX) is a hypoxia-induced, membrane-tethered enzyme that is highly expressed in many cancers. It catalyses the hydration of CO 2 to HCO3- and H+, and the reverse dehydration reaction. Recent studies have shown an important role for CAIX in pH regulation and it has been speculated that CAIX may play a role in supporting cancer progression towards more aggressive forms of the disease. Clinical correlative studies in many tumours have shown that high expression is related...

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Journal:
European Journal of Pharmacology
Volume:
657
Issue:
1-3
Pages:
173-183
Publication date:
2011-04-25
DOI:
ISSN:
0014-2999
URN:
uuid:753c514c-daa3-481a-b0df-f78b70aab336
Source identifiers:
127424
Local pid:
pubs:127424

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