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Journal article

Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase.

Abstract:

The ataxia telangiectasia-mutated (ATM) and Rad3-related kinase (ATR) is a central component of the cell cycle checkpoint machinery required to induce cell cycle arrest in response to DNA damage. Accumulating evidence suggests a role for ATR in signaling DNA damage during S-phase. Here we show that ATR is recruited to nuclear foci induced by replication fork stalling in a manner that is dependent on the single stranded binding protein replication protein A (RPA). ATR associates with chromatin...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m314212200

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
279
Issue:
16
Pages:
16433-16440
Publication date:
2004-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:75393e15-8bbc-4ac4-afd3-716e5e6fc505
Source identifiers:
100189
Local pid:
pubs:100189

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