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Greater in vivo than in vitro pulsatility of insulin secretion with synchronized insulin and somatostatin secretory pulses.

Abstract:

To examine the control of pulsatile insulin secretion by an intrapancreatic pacemaker, samples at minute intervals were taken from the portal vein in dogs in vivo and from an isolated perfused pancreas preparation in vitro. Anesthetized dogs had high amplitude pulsatile insulin secretion which was not consistently regular. Fourier transform analysis showed dominant 20- and 10-min periods of spectral power (P less than 0.01). After vagotomy, the relative oscillatory power was reduced from 83% ...

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Publication status:
Published

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Publisher copy:
10.1210/endo-120-6-2272

Authors


Matthews, DR More by this author
Hermansen, K More by this author
Connolly, AA More by this author
Schmitz, O More by this author
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Journal:
Endocrinology
Volume:
120
Issue:
6
Pages:
2272-2278
Publication date:
1987-06-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:75372c8e-4a9b-48da-a06e-c9787ed4673f
Source identifiers:
72983
Local pid:
pubs:72983

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