Journal article
The giant titin: how to evaluate its role in cardiomyopathies
- Abstract:
- Titin, the largest protein known, has attracted a lot of interest in the cardiovascular field in recent years, since the discovery that truncating variants in titin are commonly found in patients with dilated cardiomyopathy. This review will discuss the contribution of variants in titin to inherited cardiac conditions (cardiomyopathies) and how model systems, such as animals and cellular systems, can help to provide insights into underlying disease mechanisms. It will also give an outlook onto exciting technological developments, such as in the field of CRISPR, which may facilitate future research on titin variants and their contributions to cardiomyopathies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1007/s10974-019-09518-w
Authors
- Publisher:
- Springer
- Journal:
- Journal of Muscle Research and Cell Motility More from this journal
- Volume:
- 40
- Issue:
- 2
- Pages:
- 159–167
- Publication date:
- 2019-05-30
- Acceptance date:
- 2019-05-28
- DOI:
- EISSN:
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1573-2657
- ISSN:
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0142-4319
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1004804
- UUID:
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uuid:7521ebda-4f6d-4976-bea6-1854eaebde9a
- Local pid:
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pubs:1004804
- Source identifiers:
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1004804
- Deposit date:
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2019-06-01
- ARK identifier:
Terms of use
- Copyright holder:
- Azad et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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