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Onchocerciasis modulates the immune response to mycobacterial antigens.

Abstract:

Chronic helminth infection induces a type-2 cellular immune response. In contrast to this, mycobacterial infections commonly induce a type-1 immune response which is considered protective. Type-2 responses and diminished type-1 responses to mycobacteria have been previously correlated with active infection states such as pulmonary tuberculosis and lepromatous leprosy. The present study examines the immune responses of children exposed to both the helminth parasite Onchocerca volvulus and the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Journal:
Clinical and experimental immunology
Volume:
117
Issue:
3
Pages:
517-523
Publication date:
1999-09-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:751aabeb-75fa-4277-89b3-5396e256553f
Source identifiers:
383137
Local pid:
pubs:383137

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