Journal article icon

Journal article

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Abstract:
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.bmcl.2014.09.035

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
24
Issue:
21
Pages:
4954-4957
Publication date:
2014-11-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:485362
UUID:
uuid:750daacd-a6a6-40b8-8a66-fbd9d0d936cc
Local pid:
pubs:485362
Source identifiers:
485362
Deposit date:
2014-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP