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Kinase inhibitor selectivity profiling using differential scanning fluorimetry.

Abstract:

Fast, robust, and inexpensive screening methods are the heart of drug discovery processes. Moreover, it is useful to have access to several established assay formats, for validation purposes. If a targeted protein is an enzyme, the logical and widely used approach is the direct measurement of the effect of the added ligands on its activity. A variety of enzymatic assay formats have been successfully applied for inhibitor screening of protein kinases. However, enzymatic assays require an activ...

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Publisher copy:
10.1007/978-1-61779-337-0_7

Authors


Fedorov, O More by this author
Niesen, FH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
795
Pages:
109-118
Publication date:
2012
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:7508ed58-c99c-4356-8e6f-36d0690827d2
Source identifiers:
180777
Local pid:
pubs:180777

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