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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Abstract:

Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of experimental models has hampered progress. We have generated clinically annotated EAC organoid cultures that recapitulate the morphology, genomic, and transcriptomic landscape of the primary tumor including point mutations, copy number alterations, and mutational signatures. Karyotyping of organoid cultures has confirmed polyclonality reflecting the clonal architecture of the pr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-05190-9

Authors


Francies, HE More by this author
Secrier, M More by this author
Miremadi, A More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
2983
Publication date:
2018-07-30
Acceptance date:
2018-06-22
DOI:
ISSN:
2041-1723
Pubs id:
pubs:892105
URN:
uri:74fe1904-22ce-4939-8f48-d8d276fa928c
UUID:
uuid:74fe1904-22ce-4939-8f48-d8d276fa928c
Local pid:
pubs:892105
Language:
English
Keywords:

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