Latent Transforming Growth Factor-beta1 Functionalised Electrospun Scaffolds Promote Human Cartilage Differentiation: Towards an Engineered Cartilage Construct

Journal article

We have demonstrated a proof of concept for cell-mediated activation of anchored growth factors using a novel biofunctionalised scaffold in cartilage engineering. This presents a platform for development of protein delivery systems and for tissue engineering.

Authors: Lim, E-H; Sardinha, JP; Myers, S; Stevens, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Thieme
• Journal: Archives of Plastic Surgery
• Volume: 40
• Issue: 06
• Pages: 676-686
• Publication date: 2013-11-01
• DOI: 10.5999/aps.2013.40.6.676
• ISSN: 2234-6163
• Language: English
• Keywords: Biology; Biochemistry; Scaffold; Bone morphogenetic protein; Chemistry; Chondrogenesis; Pathology; Anatomy; Osteoarthritis; Cell biology; Medicine; Biomedical engineering; Growth factor; Transforming growth factor; Aggrecan; Tissue engineering; Gene; Chondrocyte; Articular cartilage; Cartilage; Growth differentiation factor