- Abstract:
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Currently, little is known about the evolution of epigenetic regulation in animal stem cells. Here we demonstrate, using the planarian stem cell system to investigate the role of the COMPASS family of MLL3/4 histone methyltransferases that their function as tumor suppressors in mammalian stem cells is conserved over a long evolutionary distance. To investigate the potential conservation of a genome-wide epigenetic regulatory program in animal stem cells, we assess the effects of Mll3/4 loss o...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 12.9MB)
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- Publisher copy:
- 10.1038/s41467-018-06092-6
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- 3633
- Publication date:
- 2018-09-07
- Acceptance date:
- 2018-08-13
- DOI:
- EISSN:
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2041-1723
- Pubs id:
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pubs:919112
- URN:
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uri:74efc357-5000-4927-9f26-dcdc41f572dc
- UUID:
-
uuid:74efc357-5000-4927-9f26-dcdc41f572dc
- Local pid:
- pubs:919112
- Language:
- English
- Keywords:
- Copyright holder:
- Mihaylova et al
- Copyright date:
- 2018
- Notes:
-
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
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