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MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199

Abstract:

Targeted therapies designed to exploit specific molecular pathways in aggressive cancers are an exciting area of current research. Mixed Lineage Leukemia (MLL) mutations such as the t(4;11) translocation cause aggressive leukemias that are refractory to conventional treatment. The t(4;11) translocation produces an MLL/AF4 fusion protein that activates key target genes through both epigenetic and transcriptional elongation mechanisms. In this study, we show that t(4;11) patient cells express h...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2015.12.003

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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Ballabio, E
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Cell reports Journal website
Volume:
13
Issue:
12
Pages:
2715-2727
Publication date:
2015-12-17
Acceptance date:
2015-11-19
DOI:
EISSN:
2211-1247
URN:
uuid:74a78d34-ffee-4b81-ae20-adf8c4a67092
Source identifiers:
585788
Local pid:
pubs:585788

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