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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

Abstract:

Recent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N-terminus of Notch ligands, which has both lipid- and receptor-binding properties. We present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. Comparisons between the Ja...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/embj.201796632

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Department:
Oxford, MSD, Pathology Dunn School
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Suckling, RJ
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Funding agency for:
Whiteman, P
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Funding agency for:
Handford, PA
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Funding agency for:
Lea, SM
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
36
Issue:
15
Pages:
2204-2215
Publication date:
2017-08-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:700723
URN:
uri:749c7405-1604-4334-8b18-eb21b79006ee
UUID:
uuid:749c7405-1604-4334-8b18-eb21b79006ee
Local pid:
pubs:700723
Language:
English
Keywords:

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