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Journal article

Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells.

Abstract:

Multiple isoforms of mammalian alpha-mannosidases are active in the pathways of N-linked glycoprotein synthesis and catabolism. They differ in specificity, function and location within the cell and can be selectively inhibited by imino sugar monosaccharide mimics. Previously, a series of structurally related novel 7-membered iminocyclitols were synthesised and found to be inhibitors of alpha-mannosidase using in vitro assays. The present study aimed to delineate alpha-mannosidases hydrolytic ...

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Publication status:
Published

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Publisher copy:
10.1007/s10719-009-9231-3

Authors


Journal:
Glycoconjugate journal
Volume:
26
Issue:
9
Pages:
1109-1116
Publication date:
2009-12-05
DOI:
EISSN:
1573-4986
ISSN:
0282-0080
URN:
uuid:74808d44-4676-4a76-98e6-1d6f93bf2499
Source identifiers:
101151
Local pid:
pubs:101151

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