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Journal article

Segregation of all four major fibrillar collagen genes in the Marfan syndrome.

Abstract:

Linkage markers at or close to the genes encoding the three major fibrillar collagens were used to analyze the segregation of these loci in six pedigrees with dominantly inherited Marfan syndrome. Four pedigrees were discordant at one of the Type I collagen loci (COL1A2), and, of these, two were discordant at the other Type I locus (COL1A1). The Marfan syndrome also segregated independently of the structural loci for Type II and Type III collagen in these two families. This is evidence agains...

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Publication status:
Published

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Authors


Ogilvie, DJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Priestley, LM More by this author
Dalgleish, R More by this author
Schmidtke, J More by this author
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Journal:
American journal of human genetics
Volume:
41
Issue:
6
Pages:
1071-1082
Publication date:
1987-12-05
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:747561fa-091d-4b39-9d88-f7a3617cbb65
Source identifiers:
108557
Local pid:
pubs:108557

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