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Resistance to collagen-induced arthritis in DBA/1 mice by intraperitoneal administration of soluble type II collagen involves both CD4+ and CD8+ T lymphocytes.

Abstract:

In this paper we report that intraperitoneal administration of type II collagen in a soluble form protects DBA/1 mice against collagen-induced arthritis (CIA) on subsequent arthritogenic challenge with soluble type II collagen in adjuvant. The degree of arthritis suppression, which is expressed in terms of reduced incidence of arthritis, delayed onset and reduced anti-collagen antibody titres, depends on the dose and timing of the pre-immunization collagen injection. In order to elucidate the...

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Publisher copy:
10.3109/08916938909014700

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Autoimmunity
Volume:
4
Issue:
4
Pages:
237-245
Publication date:
1989-01-01
DOI:
EISSN:
1607-842X
ISSN:
0891-6934
URN:
uuid:745b64d4-7de9-4f6b-b485-28e3f5c5275a
Source identifiers:
6725
Local pid:
pubs:6725

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