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Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans.

Abstract:

The mechanism whereby IL-17 drives rheumatoid arthritis remains incompletely understood. We demonstrate that anti-IL-17 therapy in collagen-induced arthritis ameliorates bone damage by reducing the number of osteoclasts in joints. We found equal numbers of CD4(+) Th17 and IL-17 producing γδ T cells in the joints of arthritic mice, and in vitro, both populations similarly induced osteoclastogenesis. However, individual depletion and adoptive transfer studies revealed that in vivo, Th17 cells d...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1003370

Authors


Pöllinger, B More by this author
Metzler, B More by this author
Walker, UA More by this author
Tyndall, A More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
186
Issue:
4
Pages:
2602-2612
Publication date:
2011-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:742994bf-af4c-4859-ab63-7dc4fbd76b98
Source identifiers:
223542
Local pid:
pubs:223542

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