Journal article

Oxidative β-C–H sulfonylation of cyclic amines

Abstract:: A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. N-iodosuccinimide facilitates regioselective oxidative sulfonylation at C–H bonds positioned β to the nitrogen atom of tertiary amines, installing enaminyl sulfone functionality in cyclic systems. Mild reaction conditions, broad functional group tolerance and a wide substrate scope are demonstrated. The nucleophilic character of the enaminyl sulfone is harnessed, demonstrating potential application for scaffold diversification

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Griffiths, R. J., Kong, W. C., Richards, S. A., Burley, G. A., Willis, M., & Talbot, E. P. A. (2018). Oxidative β-C–H sulfonylation of cyclic amines. Chemical Science, 9(8), 2295–2300.

MLA Style

Griffiths, R. J., et al. “Oxidative β-C–H Sulfonylation of Cyclic Amines.” Chemical Science, vol. 9, no. 8, Royal Society of Chemistry, 2018, pp. 2295–300.

Chicago Style

Griffiths, RJ, WC Kong, SA Richards, GA Burley, M Willis, and EPA Talbot. 2018. “Oxidative β-C–H Sulfonylation of Cyclic Amines.” Chemical Science 9 (8): 2295–2300.
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Publisher copy:: 10.1039/C7SC04900E

Authors

+ Griffiths, RJ More by this author

Role:: Author

+ Kong, WC More by this author

Role:: Author

+ Richards, SA More by this author

Role:: Author

+ Burley, GA More by this author

Role:: Author

+ Willis, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Oxford college:: Lincoln College
Role:: Author
ORCID:: 0000-0002-0636-6471

More authors...

+ GSK More from this funder

Grant:: viathe GSK/UniversityofStrathclydeCentreforDoctoralTrainingin Synthetic; MedicinalChemistry

Publisher:: Royal Society of Chemistry
Journal:: Chemical Science More from this journal
Volume:: 9
Issue:: 8
Pages:: 2295-2300
Publication date:: 2018-01-22
Acceptance date:: 2018-01-19
DOI:: 10.1039/C7SC04900E
ISSN:: 2041-6539

Pubs id:: pubs:820960
UUID:: uuid:7428f825-eb53-4e9d-ac94-2e4ffb462776
Local pid:: pubs:820960
Source identifiers:: 820960
Deposit date:: 2018-01-22

Terms of use

Copyright holder:: Griffiths et al
Copyright date:: 2018
Notes:: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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