Journal article
Plasmodium vivax trophozoites insensitive to chloroquine.
- Abstract:
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BACKGROUND: Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. However preliminary in vitro observations on P. vivax clinical isolates suggest that only ring stages (early trophozoites) are sensitive to chloroquine. In this study, the stag...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1186/1475-2875-7-94
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Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- Malaria Journal More from this journal
- Volume:
- 7
- Issue:
- 1
- Article number:
- 94
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1475-2875
- ISSN:
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1475-2875
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:27204
- UUID:
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uuid:73ed1d7f-dbeb-4b4b-9117-56ab33a66470
- Local pid:
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pubs:27204
- Source identifiers:
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27204
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Sharrock et al
- Copyright date:
- 2008
- Notes:
- © 2008 Sharrock et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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