Journal article icon

Journal article

Plasmodium vivax trophozoites insensitive to chloroquine.

Abstract:

BACKGROUND: Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. However preliminary in vitro observations on P. vivax clinical isolates suggest that only ring stages (early trophozoites) are sensitive to chloroquine. In this study, the stag...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1186/1475-2875-7-94

Authors


Sharrock, WW More by this author
Suwanarusk, R More by this author
Lek-Uthai, U More by this author
Edstein, MD More by this author
Kosaisavee, V More by this author
Expand authors...
More from this funder
Funding agency for:
Price, RN
Wellcome Trust More from this funder
Charles Darwin University More from this funder
Australian Defence Organisation More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
7
Issue:
1
Pages:
Article: 94
Publication date:
2008
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:73ed1d7f-dbeb-4b4b-9117-56ab33a66470
Source identifiers:
27204
Local pid:
pubs:27204

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP