Journal article : Review
From silence to symphony: transcriptional repression and recovery in response to DNA damage
- Abstract:
- Genotoxic stress resulting from DNA damage is resolved through a signaling cascade known as the DNA Damage Response (DDR). The repair of damaged DNA is essential for cell survival, often requiring the DDR to attenuate other cellular processes such as the cell cycle, DNA replication, and transcription of genes not involved in DDR. The complex relationship between DDR and transcription has only recently been investigated. Transcription can facilitate the DDR in response to double-strand breaks (DSBs) and stimulate nucleotide excision repair (NER). However, transcription may need to be reduced to prevent potential interference with the repair machinery. In this review, we discuss various mechanisms that regulate transcription repression in response to different types of DNA damage, categorizing them by their range and duration of effect. Finally, we explore various models of transcription recovery following DNA damage-induced repression.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.7MB, Terms of use)
-
- Publisher copy:
- 10.1080/21541264.2024.2406717
Authors
+ Cancer Research UK
More from this funder
- Funder identifier:
- https://ror.org/054225q67
- Grant:
- BVR01170
- Publisher:
- Taylor & Francis
- Journal:
- Transcription More from this journal
- Volume:
- 15
- Issue:
- 3-5
- Pages:
- 161-175
- Publication date:
- 2024-10-01
- Acceptance date:
- 2024-09-16
- DOI:
- EISSN:
-
2154-1272
- ISSN:
-
2154-1264
- Pmid:
-
39353089
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
2039001
- Local pid:
-
pubs:2039001
- Deposit date:
-
2025-02-03
- ARK identifier:
Terms of use
- Copyright holder:
- Ajit and Gullerova
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record