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Journal article

Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order.

Abstract:

The efficacies of many new T cell vaccines rely on generating large populations of long-lived pathogen-specific effector memory CD8 T cells. However, it is now increasingly recognized that prior infection history impacts on the host immune response. Additionally, the order in which these infections are acquired could have a major effect. Exploiting the ability to generate large sustained effector memory (i.e. inflationary) T cell populations from murine cytomegalovirus (MCMV) and human Adenov...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1006782

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
Austrian Science Fund More from this funder
Nuffield Dominions Trust More from this funder
Oxford University More from this funder
Oxford Martin School More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
13
Issue:
12
Pages:
e1006782
Publication date:
2017-12-01
Acceptance date:
2017-11-29
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
29281733
Source identifiers:
813024
Language:
English
Keywords:
Pubs id:
pubs:813024
UUID:
uuid:73885aae-d376-46af-a396-1b4afb8f8289
Local pid:
pubs:813024
Deposit date:
2017-12-29

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