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The burden of tuberculosis in Ho Chi Minh City, Vietnam: a spatial analysis of drug-susceptible and multi-drug resistant cases between 2020 and 2023

Abstract:
We characterised the spatial distribution of drug-susceptible (DS) and multi-drug resistant (MDR) tuberculosis (TB) cases in Ho Chi Minh City (HCMC), a major South-East Asian metropolis, and explored demographic and socioeconomic factors associated with local TB burden. Hot spots of DS- and MDR-TB incidence were observed in the central parts of HCMC, with substantial heterogeneity observed across wards. Positive spatial autocorrelation was observed for both DS- and MDR-TB. Ward-level TB incidence was associated with HIV prevalence (incidence rate ratio [IRR] 1.77, 95% CI 1.54-2.03) and the male proportion of the population (IRR 1.05, 95% CI 1.02-1.08). No ward-level demographic and socioeconomic indicators were associated with MDR-TB case count relative to total TB case count. Our findings may inform spatially-targeted TB control strategies and provide insights for generating hypotheses about the nature of the relationship between DS- and MDR-TB in HCMC, Vietnam and the wider South-East Asia region.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3201/eid3003.231309

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Brasenose; Brasenose College
Role:
Author
ORCID:
0000-0002-1584-9141


Publisher:
Centers for Disease Control and Prevention
Journal:
Emerging Infectious Diseases More from this journal
Volume:
30
Issue:
3
Pages:
499-509
Publication date:
2024-02-23
Acceptance date:
2023-12-07
DOI:
EISSN:
1080-6059
ISSN:
1080-6040


Language:
English
Keywords:
Pubs id:
1580090
Local pid:
pubs:1580090
Deposit date:
2023-12-11

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