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Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Abstract:
We found evidence of four loci associated with breast cancer-specific survival within three patient subgroups. There was limited evidence for the existence of associations in other patient subgroups. However, the power for many subgroups is limited due to the low number of events. Even so, our results suggest that the impact of common germline genetic variants on breast cancer-specific survival might be limited.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13058-021-01450-7

Authors

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Role:
Author
ORCID:
0000-0003-4983-7883
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Role:
Author
ORCID:
0000-0002-3409-3351
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Role:
Author
ORCID:
0000-0002-5452-9933
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Role:
Author
ORCID:
0000-0003-3888-8829


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Funder identifier:
10.13039/100000005
Grant:
W81XWH-10-1-0341
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Funder identifier:
10.13039/100000002
Grant:
U19 CA148065
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Funder identifier:
10.13039/501100000024
Grant:
GPH-129344
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Funder identifier:
10.13039/501100000289
Grant:
C1287/A16563


Publisher:
BioMed Central
Journal:
Breast Cancer Research More from this journal
Volume:
23
Issue:
1
Pages:
86-86
Article number:
86
Publication date:
2021-08-18
DOI:
EISSN:
1465-542X
ISSN:
1465-5411


Language:
English
Keywords:
Pubs id:
1191724
Local pid:
pubs:1191724
Source identifiers:
W3195015166
Deposit date:
2026-03-25
ARK identifier:
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