- Abstract:
-
How transcription affects the way specific genes are arranged within the nucleus remains to be fully understood. We examine here whether transcription occurs in discrete sites (factories) containing the required machinery and whether these sites specialize in transcribing different genes. We cotransfected plasmids encoding a common origin of replication but different transcription units into cells, where they are assembled into minichromosomes that the cellular machinery replicates and transc...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1083/jcb.200710053
-
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- Journal:
- The Journal of cell biology
- Volume:
- 181
- Issue:
- 4
- Pages:
- 615-623
- Publication date:
- 2008-05-05
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- URN:
-
uuid:73668501-9898-45f7-bc43-d1aaa0e32dca
- Source identifiers:
-
19691
- Local pid:
- pubs:19691
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Similar active genes cluster in specialized transcription factories.
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