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Journal article

Similar active genes cluster in specialized transcription factories.

Abstract:

How transcription affects the way specific genes are arranged within the nucleus remains to be fully understood. We examine here whether transcription occurs in discrete sites (factories) containing the required machinery and whether these sites specialize in transcribing different genes. We cotransfected plasmids encoding a common origin of replication but different transcription units into cells, where they are assembled into minichromosomes that the cellular machinery replicates and transc...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.200710053

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of cell biology
Volume:
181
Issue:
4
Pages:
615-623
Publication date:
2008-05-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:73668501-9898-45f7-bc43-d1aaa0e32dca
Source identifiers:
19691
Local pid:
pubs:19691

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